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NEUROBIOLOGY - NEUROCHEMISTRY

             
Compulsory/Elective Code Semester Lectures Practicals Credits ECTS
Elective 13B045 7th 3 Hrs/Wk  - 3 4,0
Aims:
 
 

The course deals with: 1. Development of the Nervous System - 2. Interaction of cardiovascular system and nervous system - 3. Neuroimmunology - 4. Neuroendocrinology - 5. Other mechanisms of regulation of the nervous system - 6. Cognitive functions - 7. Biochemistry of the Nervous system - 8. Principles of neurotransmission and signaling - 9. Neurotransmission systems - 10. Cholinergic neurotransmission, Catecholamines, Serotonin, Histamine, Neuropeptides, Glutamate, GABA, Purinergic System, G Proteins, Cyclic Nucleotides - 11. Biochemistry of Neuropathies

The course consists of two independent modules: Neurobiology & Neurochemistry. The course modules are taught independently and in parallel.

 
Objectives:
 
 

Upon successful completion of the course the student is expected to acquire the following knowledge, skills and abilities: 

Knowledge: a) Knowledge and ability to describe the mechanisms of development of the nervous system and its anatomy, b) Knowledge and ability to describe brain blood perfusion and regulation of blood flow, as well as the function of the blood-brain barrier, c) Knowledge and ability to describe the brain's immune system and its interaction with the peripheral immune system, d) Knowledge and ability to describe the mechanisms of interaction of the endocrine system and nervous system, e) Knowledge and ability to describe other mechanisms involved in the regulation of nervous system function such as circadian rhythms and sleep, f) Knowledge and ability to describe the molecular basis of cognitive functions, g) Understand the function and regulation of biomolecules which control the biochemical and molecular processes of the nervous system, h) Understand the function of the neurotransmitter systems and the biochemical-molecular mechanisms involved in information transfer.

Skills: a) Understand the interactions between the various cells of the brain, b) Understand the neurochemical base of neuronal function, c) Understand the role of  neurochemical systems regulation , as it applies to  the function of the nervous system, d) Understand the interactions of the various body systems with the nervous system, e) Understand how diseases are caused by means of the disturbance of the physiological relationship of the nervous system with other body systems, f) Understand the mechanisms of neurotransmission as well as their regulation, g) Understand the mechanisms of action of neurotransmitters and drugs  in neurological and psychiatric diseases.

Abilities: a) Understand the modern technologies applied in the study of physiological and pathological functions of the nervous system, b) Ability to seek employment or post- graduate education in related fields, c) Rapid and effective integration into relevant employment environments, d) Increased autonomy in related employment  environments.

 
Lectures:
 
 

NEUROBIOLOGY: Development of the Nervous System: Axonal growth and guidance, Formation and removal of synapses, Neuroprotection and neurotoxicity - Interaction of the cardiovascular system and the nervous system: Brain blood flow. Innervation of blood vessels and the Hearts, Blood Brain Barrier, Ischemia and Brain Response to Ischemia, Metabolism of the Central Nervous System - Neuroimmunology: Astrocytes - neuronal metabolism - regulation of synaptic-transmission, Microglial cells-role in synaptic transmission and removal of synapses, The role of the peripheral immune system - Neuroendocrinology: Interaction of endocrine system and nervous system - Other mechanisms of nervous system regulation:Circadian rhythms-sleep and dreams, Mobilization-reward and addiction - Cognitive functions: Emotions-Empathy-Memory and learning, Language and communication.

NEUROCHEMISTRY: Nervous System Biochemistry: Overview - General principles of chemical neurotransmission and signaling - Cholinergic Transmission - Acetylcholine - Catecholamines: Enzymology - Biosynthesis - Receptors - Serotonin: Biosynthesis - Receptors - Re-uptake - Histamine: Biological activity at the CNS and periphery - Neuropeptides, Glutamate: Action in excitatory synapses - GABA: Synthesis - Receptors - function - Purinergic system, G proteins and cyclic nucleotides in the nervous system, Role of protein phosphorylation in the function of the nervous system - Biochemistry of Neuropathies-Dependence, Amino Acid Metabolism Disorders, Epilepsy

 
Instructors:
 
  Spiros EfthimiopoulosProfessor of Animal & Human Physiology - Neurobiology (Coordinator) - Ourania E. Tsitsilonis, Professor of Immunology - Panagiota Papazafiri, Associate Professor of Animal Physiology - Dido Vassilacopoulou, Associate Professor in Biochemistry of Eukaryotic Organisms - Ioanna-Katerina Aggeli, Assistant Professor of Animal Physiology
 
Notes:
 
 

Prerequisites for the student to choose and attend the course: Animal & Human Physiology, Biochemistry, Molecular Biology, Cell Biology

The course is offered to Erasmus students: Teaching in Greek language - Exams in English language.

The evaluation process is carried out in Greek language (there is the possibility in English for Erasmus students), with a final examination of the whole course that includes essay questions and/or multiple choice questions

 
Contact:
 
  If you require more information, please contact the Course Coordinator, Prof Spiros Efthimiopoulos at Tel: +30 210 727 4890 Email: efthis[at]biol.uoa[dot]gr