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DEVELOPMENTAL BIOLOGY & HISTOLOGY

             
Compulsory/Elective Code Semester Lectures Practicals Credits ECTS
Elective 13A703 7th 4 Hrs/Wk 3 Hrs/Wk 5 6.0
Aims:
 
 

The course deals with fundamental concepts related to the Developmental Biology and Embryology through studying the development of model organisms, such as Drosophila, C. elegans, Xenopus, Zebrafish, Chick and Mouse. The aim of the course is to provide a deep understanding of the embryogenesis that depends on germ-layer (ectoderm, endoderm and mesoderm) patterning, and of the mechanisms operating for the control of regeneration, aging and birth defects. At the same time, the respective research methodology (Paraffin Embedding, Tissue Sectioning, Staining, Light Microscopy and Observation of Histological Specimens) is studied, so that the students will be able to apply, combine and analyze the results obtained by these techniques. By the end of given lectures and laboratory exercises, students are expected to: a) be able to distinguish the germ layer-origin of different organs,b) describe the various types of tissues,c) understand their cellular organization, d) know the fundamental mechanisms of the development, from Drosophila to Human, e) interpret the processes taking place during organogenesis, f) comprehend the basic mechanisms and codes for embryogenesis, regeneration and cell death, g) compare and trace the characteristics of normal growth, as opposed to spontaneous morphogenetic abnormalities, h) choose and perform classical and state-of-the-art assays applied in the field of Developmental Biology and Histology

 
Objectives:
 
 

Students are expected to: Knowledge: a) understand the differences in the structure and organization observed in the various animal organs and tissues, such as epithelial, connective, neural and muscular ones, b) learn and embed the molecular mechanisms of the development and the basic principles of embryology, through the study of model organisms, such as Drosophila, C. elegans, Xenopus, Zebrafish, Chick and Mouse, c) learn and describe the mechanisms of regeneration, aging and cell death, d) distinguish the physiologically developed structures and their organization, as compared to the morphological abnormalities and lesions, e) identify the processes of organogenesis (in organs of endodermal, mesodermal and ectodermal origin), f) learn and apply the appropriate research methodology and conventional or modern techniques required to study the Developmental Biology and Histology of a model or representative animal cell system - Skills: a) explain the molecular mechanisms of organogenesis and growth, b) be able to handle scientific instruments with ease and reliability, c) have the ability to apply and adapt the experimental data being related to Histology, Embryology and stem cells, d) interpret and relate the fundamental mechanisms of regeneration, aging and cell death from Drosophila to Human, e) recognize and classify the different types of tissues, f) develop the ability to examine and compare biological structures that are being characteristic of physiological growth, against those exhibiting spontaneous morphogenetic abnormalities - Abilities: a) combine techniques and interpret the results of their application, in order to answer biological questions about the development of animal organisms, b) interpret results, draw conclusions and make new assumptions, regarding organs’ and tissues’ structure in an animal system, c) become proficient to evaluate the physiological or pathological characteristics of model animal organisms, d) be able to compare and evaluate data being related to the essential mechanisms controlling growth and organogenesis, e) manage to compare and relate data, and make new assumptions about animal development.

 
Lectures:
 
 

Introduction in Developmental Biology (1 hour) - Developmental Genetics (2 hours) - Experimental Embryology (3 hours) - Techniques for the study of Development (3 hours) - Model organisms (2 hours) - Xenopus (3 hours) - Zebrafish (3 hours) - Chick (2 hours) - Mouse (4 hours) - Drosophila (4 hours) - Caenorhabditis elegans (4 hours) - Organization of tissues and stem cells (3 hours) - Development of the nervous system (4 hours) - Development of organs of mesodermal origin (4 hours) - Development of organs of endodermal origin (2 hours) - Imaginal discs in Drosophila (2 hours) - Growth, aging and cancer (2 hours) - Regeneration, evolution and development (2 hours)

 
Practicals:
 
 

1. Classical histological techniques - 2. Embryonic development of sea urchin - 3. Embryonic development of frog - 4. Microscopic anatomy (study of histological slides): Epithelium I - 5. Microscopic anatomy (study of histological slides): Epithelium II - 6. Microscopic anatomy (study of histological slides): Eye and Tooth - 7. Microscopic anatomy (study of histological slides): Genital System - 8. Microscopic anatomy (study of histological slides): Neural Tissue

 
Instructors:
 
  Lectures: I. Papassideri, Professor of Cell & Developmental Biology (Coordinator) - Ι. Trougakos, Associate Professor of Animal Cell Biology & Electron Microscopy - D. Stravopodis, Assistant Professor of Cell Biology & Development - M. Antonelou, Assistant Professor of Animal Cell Biology - V. Iconomidou, Assistant Professor of Biophysics/Molecular Biophysics
 
  Practicals: I. Papassideri, Professor of Cell & Developmental Biology - Ι. Trougakos, Associate Professor of Animal Cell Biology & Electron Microscopy - D. Stravopodis, Assistant Professor of Cell Biology & Development - M. Antonelou, Assistant Professor of Animal Cell Biology - Dr. O. Konstandi, Laboratory Teaching Staff - Dr. A. Velentzas, Laboratory Teaching Staff - Dr. N. Papandreou, Laboratory Teaching Staff - Dr. Z. Litou, Laboratory Teaching Staff
 
Notes:
 
 

The grade of practical work (Laboratory Exercises) being obtained from separate examination contributes 20% to the final, total, grade. Passing grades in both theoretical and practical (laboratory) examinations are required.

 
Contact:
 
  If you require more information, please contact the Course Coordinator, Prof. Dr. Issidora S. Papassideri, BSc, PhD, Professor of Cell & Developmental Biology at: Tel.: (+30) 210 727 4546 - Fax: (+30) 210 727 4742; E-mail: ipapasid[at]biol.uoa[dot]gr